8I2J

E. coli tryptophanyl-tRNA synthetase bound with a chemical fragment at the dimerization interface

Summary for 8I2J

Entry DOI	10.2210/pdb8i2j/pdb
Descriptor	Tryptophan--tRNA ligase, 1-(4-methoxyphenyl)ethanone, TRYPTOPHANYL-5'AMP, ... (5 entities in total)
Functional Keywords	tryptophanyl-trna synthetase, dimer interface, fragment screening, antibacterials, ligase
Biological source	Escherichia coli K-12
Total number of polymer chains	2
Total formula weight	77527.14
Authors	Xiang, M.,Zhou, H. (deposition date: 2023-01-14, release date: 2023-04-12, Last modification date: 2023-06-07)
Primary citation	Xiang, M.,Xia, K.,Chen, B.,Luo, Z.,Yu, Y.,Jiang, L.,Zhou, H. An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening. Nucleic Acids Res., 51:4637-4649, 2023 Cited by PubMed: 37070195 DOI: 10.1093/nar/gkad278 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation