8HUU
Crystal structure of HCoV-NL63 main protease with S217622
Summary for 8HUU
Entry DOI | 10.2210/pdb8huu/pdb |
Descriptor | 3C-like proteinase, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione (3 entities in total) |
Functional Keywords | viral protein-inhibitor complex, viral protein |
Biological source | Human coronavirus NL63 (HCoV-NL63) |
Total number of polymer chains | 2 |
Total formula weight | 65590.98 |
Authors | Zeng, X.Y.,Zhang, J.,Li, J. (deposition date: 2022-12-24, release date: 2023-06-21, Last modification date: 2024-02-07) |
Primary citation | Lin, C.,Jiang, H.,Li, W.,Zeng, P.,Zhou, X.,Zhang, J.,Li, J. Structural basis for the inhibition of coronaviral main proteases by ensitrelvir. Structure, 31:1016-1024.e3, 2023 Cited by PubMed: 37421945DOI: 10.1016/j.str.2023.06.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.71 Å) |
Structure validation
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