8HLP

Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 (apo)

Summary for 8HLP

• Entry DOI: 10.2210/pdb8hlp/pdb
• EMDB information: 34880
• Descriptor: Voltage-dependent L-type calcium channel subunit alpha, Voltage-dependent calcium channel subunit alpha-2/delta-1, Isoform 2c of Voltage-dependent L-type calcium channel subunit beta-2, ... (7 entities in total)
• Functional Keywords: apo state, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 440817.40

Authors

Wei, Y.,Yu, Z.,Zhao, Y. (deposition date: 2022-11-30, release date: 2024-04-24)

• Primary citation: Wei, Y.,Yu, Z.,Wang, L.,Li, X.,Li, N.,Bai, Q.,Wang, Y.,Li, R.,Meng, Y.,Xu, H.,Wang, X.,Dong, Y.,Huang, Z.,Zhang, X.C.,Zhao, Y.; Structural bases of inhibitory mechanism of Ca V 1.2 channel inhibitors.; Nat Commun, 15:2772-2772, 2024; PubMed: 38555290; DOI: 10.1038/s41467-024-47116-8

Experimental method

ELECTRON MICROSCOPY (3.5 Å)