8GV1

Crystal structure of anti-FX IgG fab with FAST-Ig mutations

Summary for 8GV1

Entry DOI	10.2210/pdb8gv1/pdb
Descriptor	Anti-factor X IgG fab heavy chain, Anti-factor X IgG fab light chain, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	bispecific antibody, fast-ig, nxt007, hemophilia a, factor x, immune system
Biological source	Homo sapiens More
Total number of polymer chains	2
Total formula weight	48767.08
Authors	Koga, H.,Yamano, T.,Fukami, T.A.,Sampei, Z.,Shiraiwa, H.,Torizawa, T. (deposition date: 2022-09-14, release date: 2023-06-28, Last modification date: 2023-11-29)
Primary citation	Koga, H.,Yamano, T.,Betancur, J.,Nagatomo, S.,Ikeda, Y.,Yamaguchi, K.,Nabuchi, Y.,Sato, K.,Teranishi-Ikawa, Y.,Sato, M.,Hirayama, H.,Hayasaka, A.,Torizawa, T.,Haraya, K.,Sampei, Z.,Shiraiwa, H.,Kitazawa, T.,Igawa, T.,Kuramochi, T. Efficient production of bispecific antibody by FAST-Ig TM and its application to NXT007 for the treatment of hemophilia A. Mabs, 15:2222441-2222441, 2023 Cited by PubMed: 37339067 DOI: 10.1080/19420862.2023.2222441 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.186 Å)

Structure validation