8GUZ
Crystal structure of anti-FIXa IgG fab with FAST-Ig mutations
Summary for 8GUZ
Entry DOI | 10.2210/pdb8guz/pdb |
Descriptor | Anti-factor IXa IgG fab heavy chain, Anti-factor IXa IgG fab light chain, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | bispecific antibody, fast-ig, nxt007, hemophilia a, factor ixa, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 4 |
Total formula weight | 97666.42 |
Authors | Koga, H.,Yamano, T.,Fukami, T.A.,Sampei, Z.,Shiraiwa, H.,Torizawa, T. (deposition date: 2022-09-14, release date: 2023-06-28, Last modification date: 2023-11-29) |
Primary citation | Koga, H.,Yamano, T.,Betancur, J.,Nagatomo, S.,Ikeda, Y.,Yamaguchi, K.,Nabuchi, Y.,Sato, K.,Teranishi-Ikawa, Y.,Sato, M.,Hirayama, H.,Hayasaka, A.,Torizawa, T.,Haraya, K.,Sampei, Z.,Shiraiwa, H.,Kitazawa, T.,Igawa, T.,Kuramochi, T. Efficient production of bispecific antibody by FAST-Ig TM and its application to NXT007 for the treatment of hemophilia A. Mabs, 15:2222441-2222441, 2023 Cited by PubMed: 37339067DOI: 10.1080/19420862.2023.2222441 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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