8GUE

Crystal Structure of narbomycin-bound cytochrome P450 PikC with the unnatural amino acid p-Acetyl-L-Phenylalanine incorporated at position 238

Summary for 8GUE

Entry DOI	10.2210/pdb8gue/pdb
Descriptor	Cytochrome P450 monooxygenase PikC, PROTOPORPHYRIN IX CONTAINING FE, NARBOMYCIN, ... (8 entities in total)
Functional Keywords	oxidoreductase, narbomycin-bound, pikc, unnatural amino acid
Biological source	Streptomyces venezuelae
Total number of polymer chains	2
Total formula weight	98206.74
Authors	Li, G.B.,Pan, Y.J.,Li, S.Y.,Gao, X. (deposition date: 2022-09-11, release date: 2023-02-15, Last modification date: 2023-11-29)
Primary citation	Pan, Y.,Li, G.,Liu, R.,Guo, J.,Liu, Y.,Liu, M.,Zhang, X.,Chi, L.,Xu, K.,Wu, R.,Zhang, Y.,Li, Y.,Gao, X.,Li, S. Unnatural activities and mechanistic insights of cytochrome P450 PikC gained from site-specific mutagenesis by non-canonical amino acids. Nat Commun, 14:1669-1669, 2023 Cited by PubMed: 36966128 DOI: 10.1038/s41467-023-37288-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation