8GRQ

Cryo-EM structure of BRCA1/BARD1 bound to H2AK127-UbcH5c-Ub nucleosome

Summary for 8GRQ

Entry DOI	10.2210/pdb8grq/pdb
EMDB information	34212
Descriptor	Histone H3, ZINC ION, Histone H4, ... (10 entities in total)
Functional Keywords	nucleosome, brca1/bard1, brca1, bard1, h2ak127, h2ak127-ubch5c-ub, nuclear protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	13
Total formula weight	235960.68
Authors	Ai, H.S.,Zebin, T.,Zhiheng, D.,Jiakun, T.,Liying, Z.,Jia-Bin, L.,Man, P.,Liu, L. (deposition date: 2022-09-02, release date: 2023-04-12)
Primary citation	Ai, H.S.,Tong, Z.,Deng, Z.,Tian, J.,Zhang, L.,Sun, M.,Du, Y.,Xu, Z.,Shi, Q.,Liang, L.,Zheng, Q.,Li, J.B.,Pan, M.,Liu, L. Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination. Chem, 2023 Cited by DOI: 10.1016/j.chempr.2023.01.012 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.87 Å)

Structure validation