8GLH

Crystal Structure of Human CD1b in Complex with Endogenous PC C40:5

Summary for 8GLH

• Entry DOI: 10.2210/pdb8glh/pdb
• Descriptor: T-cell surface glycoprotein CD1b, Beta-2-microglobulin, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: antigen presentation, lipid, cd1b, phospholipid, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 49358.69

Authors

Farquhar, R.,Rossjohn, J.,Shahine, A. (deposition date: 2023-03-22, release date: 2023-09-20, Last modification date: 2024-05-01)

• Primary citation: Huang, S.,Shahine, A.,Cheng, T.Y.,Chen, Y.L.,Ng, S.W.,Balaji, G.R.,Farquhar, R.,Gras, S.,Hardman, C.S.,Altman, J.D.,Tahiri, N.,Minnaard, A.J.,Ogg, G.S.,Mayfield, J.A.,Rossjohn, J.,Moody, D.B.; CD1 lipidomes reveal lipid-binding motifs and size-based antigen-display mechanisms.; Cell, 186:4583-4596.e13, 2023; PubMed: 37725977; DOI: 10.1016/j.cell.2023.08.022

Experimental method

X-RAY DIFFRACTION (1.83 Å)