8GIC

A1 Tei + Hpg: Adenylation domain 1 core construct from teicoplanin biosynthesis; 4-hydroxyphenylglycine bound

Summary for 8GIC

Entry DOI	10.2210/pdb8gic/pdb
Descriptor	Non-ribosomal peptide synthetase, MbtH-like short polypeptide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total)
Functional Keywords	amp-binding enzyme, nrps, adenylation domain, ligase
Biological source	Actinoplanes teichomyceticus More
Total number of polymer chains	4
Total formula weight	100333.98
Authors	Hansen, M.H.,Cryle, M.J. (deposition date: 2023-03-14, release date: 2023-12-06, Last modification date: 2023-12-13)
Primary citation	Hansen, M.H.,Adamek, M.,Iftime, D.,Petras, D.,Schuseil, F.,Grond, S.,Stegmann, E.,Cryle, M.J.,Ziemert, N. Resurrecting ancestral antibiotics: unveiling the origins of modern lipid II targeting glycopeptides. Nat Commun, 14:7842-7842, 2023 Cited by PubMed: 38030603 DOI: 10.1038/s41467-023-43451-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.64 Å)

Structure validation