8GHB

The structure of h12-LOX in monomeric form

Summary for 8GHB

Entry DOI	10.2210/pdb8ghb/pdb
EMDB information	40039
Descriptor	Polyunsaturated fatty acid lipoxygenase ALOX12, FE (II) ION (2 entities in total)
Functional Keywords	lipoxygenase, platelets, lipid-modifying enzyme, lipid oxidation, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	76507.35
Authors	Black, K.A.,Mobbs, J.I.,Venugopal, H.,Thal, D.M.,Glukhova, A. (deposition date: 2023-03-09, release date: 2023-08-09, Last modification date: 2024-05-01)
Primary citation	Mobbs, J.I.,Black, K.A.,Tran, M.,Burger, W.A.C.,Venugopal, H.,Holman, T.R.,Holinstat, M.,Thal, D.M.,Glukhova, A. Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors. Blood, 142:1233-1242, 2023 Cited by PubMed: 37506345 DOI: 10.1182/blood.2023020441 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.76 Å)

Structure validation