8G6I

Coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor

Summary for 8G6I

• Entry DOI: 10.2210/pdb8g6i/pdb
• EMDB information: 29770
• Descriptor: Coagulation factor VIII chimera from human and pig, NB33 light chain, NB33 heavy chain, ... (4 entities in total)
• Functional Keywords: immune system, blood clotting
• Biological source: Sus scrofa (pig); More
• Total number of polymer chains: 3
• Total formula weight: 215053.95

Authors

Childers, K.C.,Davulcu, O.,Haynes, R.M.,Lollar, P.,Doering, C.B.,Coxon, C.H.,Spiegel, P.C. (deposition date: 2023-02-15, release date: 2023-05-24, Last modification date: 2023-07-26)

• Primary citation: Childers, K.C.,Avery, N.G.,Estrada Alamo, K.A.,Davulcu, O.,Haynes, R.M.,Lollar, P.,Doering, C.B.,Coxon, C.H.,Spiegel, P.C.; Structure of coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor.; Blood, 142:197-201, 2023; PubMed: 37192299; DOI: 10.1182/blood.2023020181

Experimental method

ELECTRON MICROSCOPY (4.23 Å)