8G2O

Fab structure - Anti-ApoE-7C11 antibody

Summary for 8G2O

Entry DOI	10.2210/pdb8g2o/pdb
Descriptor	anti-ApoE-7C11 heavy chain, anti-ApoE-7C11 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	antibody, apoe, fab, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	48542.82
Authors	Marino, C.,Arboleda-Velasquez, J.F. (deposition date: 2023-02-06, release date: 2023-10-18, Last modification date: 2024-02-28)
Primary citation	Marino, C.,Perez-Corredor, P.,O'Hare, M.,Heuer, A.,Chmielewska, N.,Gordon, H.,Chandrahas, A.S.,Gonzalez-Buendia, L.,Delgado-Tirado, S.,Doan, T.H.,Vanderleest, T.E.,Arevalo-Alquichire, S.,Obar, R.A.,Ortiz-Cordero, C.,Villegas, A.,Sepulveda-Falla, D.,Kim, L.A.,Lopera, F.,Mahley, R.,Huang, Y.,Quiroz, Y.T.,Arboleda-Velasquez, J.F. APOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation. Alzheimers Dement, 20:819-836, 2024 Cited by PubMed: 37791598 DOI: 10.1002/alz.13436 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation