8G2I

Crystal Structure of PRMT4 with Compound YD1290

Summary for 8G2I

Entry DOI	10.2210/pdb8g2i/pdb
Descriptor	Histone-arginine methyltransferase CARM1, 5'-([2-(benzylcarbamamido)ethyl]{3-[N'-(3-bromophenyl)carbamimidamido]propyl}amino)-5'-deoxyadenosine, UNKNOWN ATOM OR ION, ... (4 entities in total)
Functional Keywords	prmt4, yd1290, transferase, structural genomics, psi-2, protein structure initiative, structural genomics consortium, sgc, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	41723.27
Authors	Song, X.,Dong, A.,Deng, Y.,Huang, R.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2023-02-03, release date: 2024-02-21)
Primary citation	Deng, Y.,Song, X.,Iyamu, I.D.,Dong, A.,Min, J.,Huang, R. A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors. Acta Pharm Sin B, 13:4893-4905, 2023 Cited by PubMed: 38045046 DOI: 10.1016/j.apsb.2023.07.022 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.17 Å)

Structure validation