8G2H

Crystal Structure of PRMT4 with Compound YD1113

Summary for 8G2H

• Entry DOI: 10.2210/pdb8g2h/pdb
• Descriptor: Histone-arginine methyltransferase CARM1, 5'-S-[2-(benzylcarbamamido)ethyl]-5'-thioadenosine, GLYCEROL, ... (6 entities in total)
• Functional Keywords: prmt4, yd1113, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 41613.22

Authors

Song, X.,Dong, A.,Deng, Y.,Huang, R.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2023-02-03, release date: 2023-12-13, Last modification date: 2024-02-21)

• Primary citation: Deng, Y.,Song, X.,Iyamu, I.D.,Dong, A.,Min, J.,Huang, R.; A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors.; Acta Pharm Sin B, 13:4893-4905, 2023; PubMed: 38045046; DOI: 10.1016/j.apsb.2023.07.022

Experimental method

X-RAY DIFFRACTION (1.49 Å)