8G2G

Crystal structure of PRMT3 with compound YD1113

Summary for 8G2G

Entry DOI	10.2210/pdb8g2g/pdb
Descriptor	Protein arginine N-methyltransferase 3, 5'-S-[2-(benzylcarbamamido)ethyl]-5'-thioadenosine, SULFATE ION, ... (4 entities in total)
Functional Keywords	prmt3, yd1113, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	77675.00
Authors	Song, X.,Dong, A.,Arrowsmith, C.H.,Edwards, A.M.,Deng, Y.,Huang, R.,Min, J. (deposition date: 2023-02-03, release date: 2023-04-26, Last modification date: 2024-02-21)
Primary citation	Deng, Y.,Song, X.,Iyamu, I.D.,Dong, A.,Min, J.,Huang, R. A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors. Acta Pharm Sin B, 13:4893-4905, 2023 Cited by PubMed: 38045046 DOI: 10.1016/j.apsb.2023.07.022 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.02 Å)

Structure validation