8FYF

Human TMEM175-LAMP1 transmembrane domain only complex

Summary for 8FYF

Entry DOI	10.2210/pdb8fyf/pdb
EMDB information	29572
Descriptor	Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 (2 entities in total)
Functional Keywords	complex, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	201190.87
Authors	Zhang, J.Y.,Zeng, W.Z.,Han, Y.,Jiang, Y.X. (deposition date: 2023-01-26, release date: 2023-06-28, Last modification date: 2023-08-02)
Primary citation	Zhang, J.,Zeng, W.,Han, Y.,Lee, W.R.,Liou, J.,Jiang, Y. Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel. Mol.Cell, 83:2524-2539.e7, 2023 Cited by PubMed: 37390818 DOI: 10.1016/j.molcel.2023.06.004 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.4 Å)

Structure validation