8FUF

Crystal structure of human O-GlcNAc transferase (OGT) in complex with an exosite-binding peptide (ZNF831) and UDP-GlcNAc

Summary for 8FUF

• Entry DOI: 10.2210/pdb8fuf/pdb
• Related: 8FE6 8FE7
• Descriptor: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Zinc finger protein 831, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE (3 entities in total)
• Functional Keywords: o-glcnac transferase, exosite, protein-protein interaction, complex, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 332522.76

Authors

Xie, J.,Jiang, J. (deposition date: 2023-01-17, release date: 2023-08-09, Last modification date: 2023-11-08)

• Primary citation: Blankenship, C.M.,Xie, J.,Benz, C.,Wang, A.,Ivarsson, Y.,Jiang, J.; Motif-dependent binding on the intervening domain regulates O-GlcNAc transferase.; Nat.Chem.Biol., 19:1423-1431, 2023; PubMed: 37653170; DOI: 10.1038/s41589-023-01422-2

Experimental method

X-RAY DIFFRACTION (3.69 Å)