8FOA
Cryo-EM structure of human TRPV6 in complex with the natural phytoestrogen genistein
Summary for 8FOA
Entry DOI | 10.2210/pdb8foa/pdb |
EMDB information | 29343 |
Descriptor | Transient receptor potential cation channel subfamily V member 6, CHOLESTEROL HEMISUCCINATE, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ... (6 entities in total) |
Functional Keywords | transient receptor potential v family member 6, trp, human, channel, open, trpv6, inhibitor, blocker, antagonist, genistein, phytoestrogen, isoflavone; trp channels, cancer, oncochannel, natural compound, membrane protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 367126.13 |
Authors | Neuberger, A.,Yelshanskaya, M.V.,Nadezhdin, K.D.,Sobolevsky, A.I. (deposition date: 2022-12-30, release date: 2023-05-24) |
Primary citation | Neuberger, A.,Trofimov, Y.A.,Yelshanskaya, M.V.,Nadezhdin, K.D.,Krylov, N.A.,Efremov, R.G.,Sobolevsky, A.I. Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein. Nat Commun, 14:2659-2659, 2023 Cited by PubMed: 37160865DOI: 10.1038/s41467-023-38352-5 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.66 Å) |
Structure validation
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