8FMU

Crystal structure of human Brachyury G177D variant in complex with SJF-4601

This is a non-PDB format compatible entry.

Summary for 8FMU

• Entry DOI: 10.2210/pdb8fmu/pdb
• Descriptor: T-box transcription factor T, N-(3-chloro-4-fluorophenyl)-3-[4-(dimethylamino)butanamido]-4-methoxybenzamide (3 entities in total)
• Functional Keywords: brachyury, t-box transcription factor, tbxt, tbxt c006, sjf-4601, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 44976.52

Authors

Bebenek, A.,Linhares, B.,Jaime-Figueroa, S.,Butrin, A.,Crews, C. (deposition date: 2022-12-24, release date: 2024-02-28)

• Primary citation: Chase, D.,Bebenek, A.,Nie, P.,Jaime-Figueroa, S.,Butrin, A.,Castro, D.,Linhares, B.,Crews, C.; Discovery and Development of the First Selective Brachyury Degrader; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.03 Å)