8FLK
Cryo-EM structure of STING oligomer bound to cGAMP and NVS-STG2
Summary for 8FLK
Entry DOI | 10.2210/pdb8flk/pdb |
EMDB information | 29281 |
Descriptor | Stimulator of interferon genes protein, cGAMP, 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid (3 entities in total) |
Functional Keywords | sting, innate immunity, molecular glue, immune system |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 160417.48 |
Authors | Li, J.,Canham, S.M.,Zhang, X.,Bai, X.,Feng, Y. (deposition date: 2022-12-21, release date: 2023-11-01, Last modification date: 2024-03-13) |
Primary citation | Li, J.,Canham, S.M.,Wu, H.,Henault, M.,Chen, L.,Liu, G.,Chen, Y.,Yu, G.,Miller, H.R.,Hornak, V.,Brittain, S.M.,Michaud, G.A.,Tutter, A.,Broom, W.,Digan, M.E.,McWhirter, S.M.,Sivick, K.E.,Pham, H.T.,Chen, C.H.,Tria, G.S.,McKenna, J.M.,Schirle, M.,Mao, X.,Nicholson, T.B.,Wang, Y.,Jenkins, J.L.,Jain, R.K.,Tallarico, J.A.,Patel, S.J.,Zheng, L.,Ross, N.T.,Cho, C.Y.,Zhang, X.,Bai, X.C.,Feng, Y. Activation of human STING by a molecular glue-like compound. Nat.Chem.Biol., 20:365-372, 2024 Cited by PubMed: 37828400DOI: 10.1038/s41589-023-01434-y PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4 Å) |
Structure validation
Download full validation report