8FJM

Crystal Structure of the Trypanosoma brucei DOT1A histone H3K76 methyltransferase in complex with AdoHcy - P212121 space group

Summary for 8FJM

• Entry DOI: 10.2210/pdb8fjm/pdb
• Descriptor: Histone-lysine N-methyltransferase, H3 lysine-79 specific, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, ... (6 entities in total)
• Functional Keywords: histone lysine methyltransferase, histone-modifying enzyme, dot1a, trypanosoma brucei, adohcy complex, transferase
• Biological source: Trypanosoma brucei brucei TREU927
• Total number of polymer chains: 2
• Total formula weight: 59690.36

Authors

Frisbie, V.S.,Hashimoto, H.,Debler, E.W. (deposition date: 2022-12-20, release date: 2024-02-07)

• Primary citation: Frisbie, V.S.,Hashimoto, H.,Xie, Y.,Baeza, J.,Nguyen, T.,Yuan, Z.,Garcia, B.A.,Debler, E.W.; Structure and Mechanism of the atypical Trypanosoma brucei DOT1A histone H3K76 methyltransferase; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)