8FHT

Cryo-EM structure of human NCC

Summary for 8FHT

Entry DOI	10.2210/pdb8fht/pdb
EMDB information	29103
Descriptor	Solute carrier family 12 member 3, SODIUM ION, CHLORIDE ION (3 entities in total)
Functional Keywords	membrane transporter, membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	226676.32
Authors	Zhang, J.,Fan, M.,Feng, L. (deposition date: 2022-12-15, release date: 2023-02-15, Last modification date: 2023-03-08)
Primary citation	Fan, M.,Zhang, J.,Lee, C.L.,Zhang, J.,Feng, L. Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter. Nature, 614:788-793, 2023 Cited by PubMed: 36792826 DOI: 10.1038/s41586-023-05718-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.02 Å)

Structure validation