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8FHN

Cryo-EM structure of human NCC (class 2)

Summary for 8FHN
Entry DOI10.2210/pdb8fhn/pdb
EMDB information29096
DescriptorSolute carrier family 12 member 2,Solute carrier family 12 member 3 chimera, ADENOSINE-5'-TRIPHOSPHATE, Polythiazide (3 entities in total)
Functional Keywordsmembrane transporter, membrane protein
Biological sourceDanio rerio (Zebrafish, Brachydanio rerio)
More
Total number of polymer chains3
Total formula weight363010.62
Authors
Zhang, J.,Fan, M.,Feng, L. (deposition date: 2022-12-14, release date: 2023-02-15, Last modification date: 2023-03-08)
Primary citationFan, M.,Zhang, J.,Lee, C.L.,Zhang, J.,Feng, L.
Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.
Nature, 614:788-793, 2023
Cited by
PubMed: 36792826
DOI: 10.1038/s41586-023-05718-0
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (3 Å)
Structure validation

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