8FFJ

Structure of Zanidatamab bound to HER2

Summary for 8FFJ

• Entry DOI: 10.2210/pdb8ffj/pdb
• EMDB information: 29044
• Descriptor: Receptor tyrosine-protein kinase erbB-2, Zanidatamab Heavy Chain A, Zanidatamab Light Chain A, ... (4 entities in total)
• Functional Keywords: antibody, biparatopic, transferase-immune system complex, transferase/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 194044.89

Authors

Worrall, L.J.,Atkinson, C.E.,Sanches, M.,Dixit, S.,Strynadka, N.C.J. (deposition date: 2022-12-08, release date: 2023-02-22)

• Primary citation: Weisser, N.,Wickman, G.,Sanches, M.,Escobar-Cabrera, E.,O'Toole, J.,Abraham, L.,Guedia, J.,Baichoo, P.,Volkers, G.,Schrag, J.,Choi, K.,Grothe, S.,Baardsnes, J.,Worrall, L.J.,Atkinson, C.E.,Harbourne, B.,Cheng, C.W.,Whalen, E.,Smith, J.,Zwierzchowski, P.,Zwaagstra, J.,Jolicoeur, N.,Lippens, J.,Fung, V.,Black, S.,Dargahi, D.,Samiotakis, A.,Chan, P.,Stevens, C.,Farber, P.,Mukhopadhyay, A.,Browman, D.,Strynadka, N.C.J.,Gold, M.R.,Dixit, S.; Zanidatamab, an Anti-HER2 Biparatopic that Induces Unique Surface HER2 Clusters and Complement-Dependent Cytotoxicity; To be Published,

Experimental method

ELECTRON MICROSCOPY (7.5 Å)