8FCA

Cryo-EM structure of the human TRPV4 - RhoA in complex with 4alpha-Phorbol 12,13-didecanoate

Summary for 8FCA

Entry DOI	10.2210/pdb8fca/pdb
EMDB information	28978
Descriptor	Transient receptor potential cation channel subfamily V member 4, (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, CHOLESTEROL HEMISUCCINATE (3 entities in total)
Functional Keywords	trpv4, rhoa, 4alpha-phorbol 12, 13-didecanoate, 4a-pdd, membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	412869.82
Authors	Kwon, D.H.,Lee, S.-Y.,Zhang, F. (deposition date: 2022-12-01, release date: 2023-07-12)
Primary citation	Kwon, D.H.,Zhang, F.,McCray, B.A.,Feng, S.,Kumar, M.,Sullivan, J.M.,Im, W.,Sumner, C.J.,Lee, S.Y. TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14:3732-3732, 2023 Cited by PubMed: 37353484 DOI: 10.1038/s41467-023-39345-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.41 Å)

Structure validation