8FBQ

Crystal structure of Plasmodium vivax glycylpeptide N-tetradecanoyltransferase (N-myristoyltransferase, NMT) bound to myristoyl-CoA and inhibitor 12b

Summary for 8FBQ

Entry DOI	10.2210/pdb8fbq/pdb
Descriptor	Glycylpeptide N-tetradecanoyltransferase, TETRAETHYLENE GLYCOL, TRIETHYLENE GLYCOL, ... (12 entities in total)
Functional Keywords	enzyme, inhibitor, complex, structural genomics, seattle structural genomics center for infectious disease, ssgcid, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Plasmodium vivax
Total number of polymer chains	1
Total formula weight	48454.53
Authors	Fenwick, M.K.,Staker, B.L.,Lovell, S.W.,Phan, I.Q.,Early, J.,Myler, P.J.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2022-11-29, release date: 2023-10-18)
Primary citation	Rodriguez-Hernandez, D.,Vijayan, K.,Zigweid, R.,Fenwick, M.K.,Sankaran, B.,Roobsoong, W.,Sattabongkot, J.,Glennon, E.K.K.,Myler, P.J.,Sunnerhagen, P.,Staker, B.L.,Kaushansky, A.,Grotli, M. Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts. Nat Commun, 14:5408-5408, 2023 Cited by PubMed: 37669940 DOI: 10.1038/s41467-023-41119-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation