8FAJ

OXA-48-NA-1-157 inhibitor complex

Summary for 8FAJ

• Entry DOI: 10.2210/pdb8faj/pdb
• Descriptor: Beta-lactamase, (5R)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-5-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: beta-lactamase, carbapenemase, inhibitor, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 2
• Total formula weight: 62083.27

Authors

Smith, C.A.,Stewart, N.K.,Toth, M.,Vakulenko, S.B. (deposition date: 2022-11-28, release date: 2023-10-11)

• Primary citation: Smith, C.A.,Stewart, N.K.,Toth, M.,Quan, P.,Buynak, J.D.,Vakulenko, S.B.; The C5 alpha-Methyl-Substituted Carbapenem NA-1-157 Exhibits Potent Activity against Klebsiella spp. Isolates Producing OXA-48-Type Carbapenemases.; Acs Infect Dis., 9:1123-1136, 2023; PubMed: 37130087; DOI: 10.1021/acsinfecdis.3c00059

Experimental method

X-RAY DIFFRACTION (1.75 Å)