8F9Z

Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with NBD-14204, an HIV-1 gp120 antagonist

Summary for 8F9Z

Entry DOI	10.2210/pdb8f9z/pdb
Descriptor	HIV-1 gp120 core, 2-acetamido-2-deoxy-beta-D-glucopyranose, (5M)-N-{(1S)-2-amino-1-[5-(hydroxymethyl)-1,3-thiazol-2-yl]ethyl}-5-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrrole-2-carboxamide, ... (5 entities in total)
Functional Keywords	hiv-1, nbd-14204, small molecules, cd4-gp120 binding inhibitor, antagonist, viral protein-inhibitor complex, viral protein/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	41137.32
Authors	Kwon, Y.D.,Kwong, P.D. (deposition date: 2022-11-25, release date: 2023-01-11, Last modification date: 2023-09-20)
Primary citation	Curreli, F.,Kwon, Y.D.,Nicolau, I.,Burgos, G.,Altieri, A.,Kurkin, A.V.,Verardi, R.,Kwong, P.D.,Debnath, A.K. Antiviral Activity and Crystal Structures of HIV-1 gp120 Antagonists. Int J Mol Sci, 23:-, 2022 Cited by PubMed: 36555641 DOI: 10.3390/ijms232415999 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation