8F9M

HIV Env germline targeting BG505_MD64_N332-GT5 SOSIP in complex with V3-glycan polyclonal Fab isolated from immunized wild type mice, and NHP monoclonal Fab RM20A3

This is a non-PDB format compatible entry.

Summary for 8F9M

• Entry DOI: 10.2210/pdb8f9m/pdb
• EMDB information: 28942 28945
• Descriptor: BG505_MD64_N332-GT5 gp120, RM20A3 Fab Heavy Chain, RM20A3 Fab Light Chain, ... (9 entities in total)
• Functional Keywords: mouse antibody, germline targeting, hiv-1, vaccine design, polyclonal, viral protein-immune system complex, viral protein/immune system
• Biological source: synthetic construct; More
• Total number of polymer chains: 14
• Total formula weight: 331295.09

Authors

Ozorowski, G.,Ward, A.B. (deposition date: 2022-11-23, release date: 2024-05-15, Last modification date: 2024-05-29)

• Primary citation: Xie, Z.,Lin, Y.C.,Steichen, J.M.,Ozorowski, G.,Kratochvil, S.,Ray, R.,Torres, J.L.,Liguori, A.,Kalyuzhniy, O.,Wang, X.,Warner, J.E.,Weldon, S.R.,Dale, G.A.,Kirsch, K.H.,Nair, U.,Baboo, S.,Georgeson, E.,Adachi, Y.,Kubitz, M.,Jackson, A.M.,Richey, S.T.,Volk, R.M.,Lee, J.H.,Diedrich, J.K.,Prum, T.,Falcone, S.,Himansu, S.,Carfi, A.,Yates 3rd, J.R.,Paulson, J.C.,Sok, D.,Ward, A.B.,Schief, W.R.,Batista, F.D.; mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies.; Science, 384:eadk0582-eadk0582, 2024; PubMed: 38753770; DOI: 10.1126/science.adk0582

Experimental method

ELECTRON MICROSCOPY (4.1 Å)