8F51
Crystal structure of acetyltransferase Eis from M. tuberculosis in complex with mefloquine
Summary for 8F51
| Entry DOI | 10.2210/pdb8f51/pdb |
| Descriptor | N-acetyltransferase Eis, Mefloquine, DIMETHYL SULFOXIDE, ... (6 entities in total) |
| Functional Keywords | drug resistance, inhibitor, acetylation, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Mycobacterium tuberculosis H37Rv |
| Total number of polymer chains | 1 |
| Total formula weight | 46944.08 |
| Authors | Pang, A.H.,Punetha, A.,Garneau-Tsodikova, S.,Tsodikov, O.V. (deposition date: 2022-11-11, release date: 2023-02-01, Last modification date: 2023-10-25) |
| Primary citation | Pang, A.H.,Green, K.D.,Punetha, A.,Thamban Chandrika, N.,Howard, K.C.,Garneau-Tsodikova, S.,Tsodikov, O.V. Discovery and Mechanistic Analysis of Structurally Diverse Inhibitors of Acetyltransferase Eis among FDA-Approved Drugs. Biochemistry, 62:710-721, 2023 Cited by PubMed: 36657084DOI: 10.1021/acs.biochem.2c00658 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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