8F4R

Gentamicin bound aminoglycoside efflux pump AcrD

Summary for 8F4R

• Entry DOI: 10.2210/pdb8f4r/pdb
• EMDB information: 28857
• Descriptor: Efflux pump membrane transporter, (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL (2 entities in total)
• Functional Keywords: aminoglycoside efflux pump, acrd, e.coli, membrane protein
• Biological source: Escherichia coli
• Total number of polymer chains: 3
• Total formula weight: 339869.22

Authors

Zhang, Z. (deposition date: 2022-11-11, release date: 2022-12-28, Last modification date: 2023-03-08)

• Primary citation: Zhang, Z.,Morgan, C.E.,Cui, M.,Yu, E.W.; Cryo-EM Structures of AcrD Illuminate a Mechanism for Capturing Aminoglycosides from Its Central Cavity.; Mbio, 14:e0338322-e0338322, 2023; PubMed: 36625574; DOI: 10.1128/mbio.03383-22

Experimental method

ELECTRON MICROSCOPY (3.06 Å)