8F1F

Structure of K48-linked tri-ubiquitin in complex with cyclic peptide

Summary for 8F1F

Entry DOI	10.2210/pdb8f1f/pdb
Descriptor	Ubiquitin, Non-proteinogenic cyclic peptide (inhibitor), GLYCEROL, ... (7 entities in total)
Functional Keywords	complex, therapeutic peptide, lys48-linked polyubiquitin, macrocyclic peptide, inhibitor of ubiquitin signaling, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	55291.38
Authors	Lubkowski, J.,Fushman, D.,Lemma, B. (deposition date: 2022-11-05, release date: 2023-11-01, Last modification date: 2023-11-15)
Primary citation	Lemma, B.,Zhang, D.,Vamisetti, G.B.,Wentz, B.G.,Suga, H.,Brik, A.,Lubkowski, J.,Fushman, D. Mechanism of selective recognition of Lys48-linked polyubiquitin by macrocyclic peptide inhibitors of proteasomal degradation. Nat Commun, 14:7212-7212, 2023 Cited by PubMed: 37938554 DOI: 10.1038/s41467-023-43025-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation