8EYD

Plasmodium falciparum M1 in complex with inhibitor 15ah

Summary for 8EYD

Entry DOI	10.2210/pdb8eyd/pdb
Descriptor	M1 family aminopeptidase, GLYCEROL, N-[(1R)-1-(4-bromophenyl)-2-(hydroxyamino)-2-oxoethyl]-N~2~-(4-fluorophenyl)glycinamide, ... (5 entities in total)
Functional Keywords	malaria, metalloaminopeptidase, inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Plasmodium falciparum (malaria parasite P. falciparum)
Total number of polymer chains	1
Total formula weight	105387.68
Authors	Calic, P.P.S.,McGowan, S.,Webb, C.T. (deposition date: 2022-10-26, release date: 2023-01-18, Last modification date: 2023-10-25)
Primary citation	Calic, P.P.S.,Vinh, N.B.,Webb, C.T.,Malcolm, T.R.,Ngo, A.,Lowes, K.,Drinkwater, N.,McGowan, S.,Scammells, P.J. Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation. Eur.J.Med.Chem., 248:115051-115051, 2022 Cited by PubMed: 36634455 DOI: 10.1016/j.ejmech.2022.115051 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.83 Å)

Structure validation