8EWZ

Plasmodium falciparum M1 in complex with inhibitor 9c

Summary for 8EWZ

Entry DOI	10.2210/pdb8ewz/pdb
Descriptor	M1 family aminopeptidase, (2R)-2-(cyclopentylcarbamamido)-N-hydroxy-2-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)acetamide, DIMETHYL SULFOXIDE, ... (7 entities in total)
Functional Keywords	malaria, metalloaminopeptidase, inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Plasmodium falciparum (malaria parasite P. falciparum)
Total number of polymer chains	1
Total formula weight	105850.49
Authors	Calic, P.P.S.,McGowan, S.,Webb, C.T. (deposition date: 2022-10-24, release date: 2023-01-18, Last modification date: 2023-10-25)
Primary citation	Calic, P.P.S.,Vinh, N.B.,Webb, C.T.,Malcolm, T.R.,Ngo, A.,Lowes, K.,Drinkwater, N.,McGowan, S.,Scammells, P.J. Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation. Eur.J.Med.Chem., 248:115051-115051, 2022 Cited by PubMed: 36634455 DOI: 10.1016/j.ejmech.2022.115051 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation