8EWY

Structure of Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain

Summary for 8EWY

Entry DOI	10.2210/pdb8ewy/pdb
EMDB information	28649
Descriptor	Tyrosine-protein kinase, Interferon lambda receptor 1, ADENOSINE, ... (4 entities in total)
Functional Keywords	jak, kinase, cytokine, signaling protein
Biological source	Mus musculus (house mouse) More
Total number of polymer chains	4
Total formula weight	293233.32
Authors	Caveney, N.A.,Saxton, R.A.,Waghray, D.,Garcia, K.C. (deposition date: 2022-10-24, release date: 2023-03-08, Last modification date: 2023-03-22)
Primary citation	Caveney, N.A.,Saxton, R.A.,Waghray, D.,Glassman, C.R.,Tsutsumi, N.,Hubbard, S.R.,Garcia, K.C. Structural basis of Janus kinase trans-activation. Cell Rep, 42:112201-112201, 2023 Cited by PubMed: 36867534 DOI: 10.1016/j.celrep.2023.112201 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (5.5 Å)

Structure validation