8EWN

Crystal structure of CYP3A4 bound to an inhibitor

Summary for 8EWN

Entry DOI	10.2210/pdb8ewn/pdb
Descriptor	Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, {N-[([2,2'-bipyridin]-5-yl-kappa~2~N~1~,N~1'~)methyl]-3-(pyridin-4-yl)propanamide}bis[3,5-difluoro-2-(pyridin-2-yl-kappaN)phenyl-kappaC~1~]iridium(1+), ... (4 entities in total)
Functional Keywords	cytochrome p450, cyp3a4, inhibitor, complex, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	57265.23
Authors	Sevrioukova, I.F. (deposition date: 2022-10-24, release date: 2023-02-01, Last modification date: 2023-10-25)
Primary citation	Denison, M.,Ahrens, J.J.,Dunbar, M.N.,Warmahaye, H.,Majeed, A.,Turro, C.,Kocarek, T.A.,Sevrioukova, I.F.,Kodanko, J.J. Dynamic Ir(III) Photosensors for the Major Human Drug-Metabolizing Enzyme Cytochrome P450 3A4. Inorg.Chem., 62:3305-3320, 2023 Cited by PubMed: 36758158 DOI: 10.1021/acs.inorgchem.3c00059 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation