8EVF

HUMAN DNA POLYMERASE ETA EXTENSION COMPLEX WITH AN INCOMING DCTP

Summary for 8EVF

• Entry DOI: 10.2210/pdb8evf/pdb
• Descriptor: DNA polymerase eta, DNA 5'-D(P*TP*GP*(MO1)P*TP*GP*AP*CP*GP*CP*T-3', DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*G)-3'), ... (6 entities in total)
• Functional Keywords: dna damage, dna polymerase, lesion bypass, y-family polymerase, translesion dna synthesis (tls), dna binding protein, transferase-dna complex, replication, transferase/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 55347.08

Authors

Pallan, P.S.,Egli, M. (deposition date: 2022-10-20, release date: 2023-08-02, Last modification date: 2023-08-30)

• Primary citation: Richie-Jannetta, R.,Pallan, P.,Kingsley, P.J.,Kamdar, N.,Egli, M.,Marnett, L.J.; The peroxidation-derived DNA adduct, 6-oxo-M 1 dG, is a strong block to replication by human DNA polymerase eta.; J.Biol.Chem., 299:105067-105067, 2023; PubMed: 37468099; DOI: 10.1016/j.jbc.2023.105067

Experimental method

X-RAY DIFFRACTION (2.87 Å)