8ESV

Structure of human ADAM10-Tspan15 complex bound to 11G2 vFab

Summary for 8ESV

Entry DOI	10.2210/pdb8esv/pdb
EMDB information	28580
Descriptor	Disintegrin and metalloproteinase domain-containing protein 10, 4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE, CHOLESTEROL HEMISUCCINATE, ... (11 entities in total)
Functional Keywords	protease, metalloprotease, tetraspanin, sheddase, adhesion, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	146651.73
Authors	Lipper, C.H.,Blacklow, S.C. (deposition date: 2022-10-14, release date: 2023-06-14, Last modification date: 2023-08-30)
Primary citation	Lipper, C.H.,Egan, E.D.,Gabriel, K.H.,Blacklow, S.C. Structural basis for membrane-proximal proteolysis of substrates by ADAM10. Cell, 186:3632-3641.e10, 2023 Cited by PubMed: 37516108 DOI: 10.1016/j.cell.2023.06.026 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.3 Å)

Structure validation