8EC6
Cryo-EM structure of the Glutaminase C core filament (fGAC)
Summary for 8EC6
Entry DOI | 10.2210/pdb8ec6/pdb |
EMDB information | 28013 |
Descriptor | Isoform 2 of Glutaminase kidney isoform, mitochondrial, PHOSPHATE ION (2 entities in total) |
Functional Keywords | mitochondria, filament, hydrolase |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 8 |
Total formula weight | 427375.46 |
Authors | Ambrosio, A.L.,Dias, S.M.,Quesnay, J.E.,Portugal, R.V.,Cassago, A.,van Heel, M.G.,Islam, Z.,Rodrigues, C.T. (deposition date: 2022-09-01, release date: 2023-09-20, Last modification date: 2023-12-27) |
Primary citation | Adamoski, D.,Dias, M.M.,Quesnay, J.E.N.,Yang, Z.,Zagoriy, I.,Steyer, A.M.,Rodrigues, C.T.,da Silva Bastos, A.C.,da Silva, B.N.,Costa, R.K.E.,de Abreu, F.M.O.,Islam, Z.,Cassago, A.,van Heel, M.G.,Consonni, S.R.,Mattei, S.,Mahamid, J.,Portugal, R.V.,Ambrosio, A.L.B.,Dias, S.M.G. Molecular mechanism of glutaminase activation through filamentation and the role of filaments in mitophagy protection. Nat.Struct.Mol.Biol., 30:1902-1912, 2023 Cited by PubMed: 37857822DOI: 10.1038/s41594-023-01118-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
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