8E90

Inhibition of Human Menin by SNDX-5613

Summary for 8E90

• Entry DOI: 10.2210/pdb8e90/pdb
• Related: 7UJ4
• Descriptor: Isoform 2 of Menin, 2-({4-[7-({(1r,4r)-4-[(ethanesulfonyl)amino]cyclohexyl}methyl)-2,7-diazaspiro[3.5]nonan-2-yl]pyrimidin-5-yl}oxy)-N-ethyl-5-fluoro-N-(propan-2-yl)benzamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: human menin, transcription, m322i mutant inhibitor complex, sndx-5613
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 111377.57

Authors

McKeever, B.M.,KULKARNI, S.,McGeehan, G.M. (deposition date: 2022-08-26, release date: 2022-12-14, Last modification date: 2023-10-25)

• Primary citation: Perner, F.,Stein, E.M.,Wenge, D.V.,Singh, S.,Kim, J.,Apazidis, A.,Rahnamoun, H.,Anand, D.,Marinaccio, C.,Hatton, C.,Wen, Y.,Stone, R.M.,Schaller, D.,Mowla, S.,Xiao, W.,Gamlen, H.A.,Stonestrom, A.J.,Persaud, S.,Ener, E.,Cutler, J.A.,Doench, J.G.,McGeehan, G.M.,Volkamer, A.,Chodera, J.D.,Nowak, R.P.,Fischer, E.S.,Levine, R.L.,Armstrong, S.A.,Cai, S.F.; MEN1 mutations mediate clinical resistance to menin inhibition.; Nature, 615:913-919, 2023; PubMed: 36922589; DOI: 10.1038/s41586-023-05755-9

Experimental method

X-RAY DIFFRACTION (1.85 Å)