8E7N

Crystal structure of beluga whale Gammacoronavirus SW1 Mpro with GC-376 captured in two conformational states

Summary for 8E7N

Entry DOI	10.2210/pdb8e7n/pdb
Related PRD ID	PRD_002495
Descriptor	main protease, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, (1R,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, ... (5 entities in total)
Functional Keywords	gammacoronavirus, protease, drug resistance, complex, hydrolase, durg discovery, main protease, mpro, substrate complex, gc-376, viral protein, viral protein-hydrolase-inhibitor complex, sw1, beluga whale, whale
Biological source	Beluga whale coronavirus SW1
Total number of polymer chains	2
Total formula weight	69518.77
Authors	Shaqra, A.M.,Schiffer, C.A. (deposition date: 2022-08-24, release date: 2023-03-29, Last modification date: 2024-04-03)
Primary citation	Zvornicanin, S.N.,Shaqra, A.M.,Huang, Q.J.,Ornelas, E.,Moghe, M.,Knapp, M.,Moquin, S.,Dovala, D.,Schiffer, C.A.,Kurt Yilmaz, N. Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses. Viruses, 15:-, 2023 Cited by PubMed: 36992489 DOI: 10.3390/v15030781 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation