8E08

Crystal structure of HPSE P6 in complex with tetraose pentosan inhibitor

Summary for 8E08

• Entry DOI: 10.2210/pdb8e08/pdb
• Descriptor: Heparanase 50 kDa subunit, Heparanase 8 kDa subunit, 2,3,4-tri-O-sulfo-beta-D-xylopyranose-(1-4)-2,3-di-O-sulfo-beta-D-xylopyranose-(1-4)-2,3-di-O-sulfo-beta-D-xylopyranose-(1-4)-2,3-di-O-sulfo-beta-D-xylopyranose, ... (6 entities in total)
• Functional Keywords: heparanase, heparan sulfate, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 57754.75

Authors

Whitefield, C.,Jackson, C.J. (deposition date: 2022-08-08, release date: 2023-07-12, Last modification date: 2023-10-25)

• Primary citation: Whitefield, C.,Vo, Y.,Schwartz, B.D.,Hepburn, C.,Ahmed, F.H.,Onagi, H.,Banwell, M.G.,Nelms, K.,Malins, L.R.,Jackson, C.J.; Complex Inhibitory Mechanism of Glycomimetics with Heparanase.; Biochemistry, 62:2202-2215, 2023; PubMed: 37368361; DOI: 10.1021/acs.biochem.3c00038

Experimental method

X-RAY DIFFRACTION (1.93 Å)