8DZ8

Neoleukin 4, a de novo designed IL-4 mimetic

Summary for 8DZ8

Entry DOI	10.2210/pdb8dz8/pdb
Descriptor	neoleukin-4 (1 entity in total)
Functional Keywords	designed protein, cytokine, de novo protein
Biological source	synthetic construct
Total number of polymer chains	8
Total formula weight	94083.86
Authors	Jude, K.M.,Spangler, J.B.,Garcia, K.C. (deposition date: 2022-08-06, release date: 2023-03-29, Last modification date: 2023-10-25)
Primary citation	Yang, H.,Ulge, U.Y.,Quijano-Rubio, A.,Bernstein, Z.J.,Maestas, D.R.,Chun, J.H.,Wang, W.,Lin, J.X.,Jude, K.M.,Singh, S.,Orcutt-Jahns, B.T.,Li, P.,Mou, J.,Chung, L.,Kuo, Y.H.,Ali, Y.H.,Meyer, A.S.,Grayson, W.L.,Heller, N.M.,Garcia, K.C.,Leonard, W.J.,Silva, D.A.,Elisseeff, J.H.,Baker, D.,Spangler, J.B. Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds. Nat.Chem.Biol., 19:1127-1137, 2023 Cited by PubMed: 37024727 DOI: 10.1038/s41589-023-01313-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.972 Å)

Structure validation