8DUK

Estrogen Receptor Alpha Ligand Binding Domain in Complex with (6'-hydroxy-1'-(4-(2-(methylamino)ethoxy)phenyl)-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl)(phenyl)methanone

Summary for 8DUK

• Entry DOI: 10.2210/pdb8duk/pdb
• Descriptor: Estrogen receptor, [(1'R)-6'-hydroxy-1'-{4-[2-(methylamino)ethoxy]phenyl}-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl](phenyl)methanone (3 entities in total)
• Functional Keywords: antiestrogen, breast cancer, alpha helical bundle, estrogen receptor, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 117846.16

Authors

Hancock, G.R.,Young, K.S.,Hosfield, D.J.,Joiner, C.,Sullivan, E.A.,Yildz, Y.,Laine, M.,Greene, G.L.,Fanning, S.W. (deposition date: 2022-07-27, release date: 2023-07-05, Last modification date: 2023-10-25)

• Primary citation: Hancock, G.R.,Young, K.S.,Hosfield, D.J.,Joiner, C.,Sullivan, E.A.,Yildz, Y.,Laine, M.,Greene, G.L.,Fanning, S.W.; Estrogen Receptor Alpha Ligand Binding Domain in Complex with (6'-hydroxy-1'-(4-(2-(methylamino)ethoxy)phenyl)-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl)(phenyl)methanone; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)