8DSD

Human NAMPT in complex with substrate NAM and small molecule activator NP-A1-S

Summary for 8DSD

• Entry DOI: 10.2210/pdb8dsd/pdb
• Descriptor: Nicotinamide phosphoribosyltransferase, NICOTINAMIDE, PHOSPHATE ION, ... (7 entities in total)
• Functional Keywords: nad biosynthesis enzyme:activator complex, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 114910.01

Authors

Ratia, K.,Xiong, R.,Shen, Z.,Thatcher, G.R. (deposition date: 2022-07-22, release date: 2023-03-08, Last modification date: 2023-10-25)

• Primary citation: Ratia, K.M.,Shen, Z.,Gordon-Blake, J.,Lee, H.,Laham, M.S.,Krider, I.S.,Christie, N.,Ackerman-Berrier, M.,Penton, C.,Knowles, N.G.,Musku, S.R.,Fu, J.,Velma, G.R.,Xiong, R.,Thatcher, G.R.J.; Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD.; Biochemistry, 62:923-933, 2023; PubMed: 36746631; DOI: 10.1021/acs.biochem.2c00655

Experimental method

X-RAY DIFFRACTION (1.429 Å)