8DS5

X-ray structure of the MK5890 Fab - CD27 antibody-antigen complex

Summary for 8DS5

Entry DOI	10.2210/pdb8ds5/pdb
Descriptor	CD27 antigen, MK-5890 Fab light chain, MK-5890 Fab heavy chain, ... (6 entities in total)
Functional Keywords	complex, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	66905.52
Authors	Fischmann, T.O. (deposition date: 2022-07-21, release date: 2022-09-28, Last modification date: 2023-10-18)
Primary citation	Guelen, L.,Fischmann, T.O.,Wong, J.,Mauze, S.,Guadagnoli, M.,Babala, N.,Wagenaars, J.,Juan, V.,Rosen, D.,Prosise, W.,Habraken, M.,Lodewijks, I.,Gu, D.,Stammen-Vogelzangs, J.,Yu, Y.,Baker, J.,Lutje Hulsik, D.,Driessen-Engels, L.,Malashock, D.,Kreijtz, J.,Bertens, A.,de Vries, E.,Bovens, A.,Bramer, A.,Zhang, Y.,Wnek, R.,Troth, S.,Chartash, E.,Dobrenkov, K.,Sadekova, S.,van Elsas, A.,Cheung, J.K.,Fayadat-Dilman, L.,Borst, J.,Beebe, A.M.,Van Eenennaam, H. Preclinical characterization and clinical translation of pharmacodynamic markers for MK-5890: a human CD27 activating antibody for cancer immunotherapy. J Immunother Cancer, 10:-, 2022 Cited by PubMed: 36100308 DOI: 10.1136/jitc-2022-005049 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.926 Å)

Structure validation