8DHH

DHODH IN COMPLEX WITH LIGAND 29

Summary for 8DHH

Entry DOI	10.2210/pdb8dhh/pdb
Descriptor	Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (8 entities in total)
Functional Keywords	dihydroorotate dehydrogenase, dhodh, oxidoreductase, inhibitor, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	41511.27
Authors	Shaffer, P.L. (deposition date: 2022-06-27, release date: 2022-08-17, Last modification date: 2023-10-18)
Primary citation	Cisar, J.S.,Pietsch, C.,DeRatt, L.G.,Jacoby, E.,Kazmi, F.,Keohane, C.,Legenski, K.,Matico, R.,Shaffer, P.,Simonnet, Y.,Tanner, A.,Wang, C.Y.,Wang, W.,Attar, R.,Edwards, J.P.,Kuduk, S.D. N -Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia. J.Med.Chem., 65:11241-11256, 2022 Cited by PubMed: 35925768 DOI: 10.1021/acs.jmedchem.2c00788 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.02 Å)

Structure validation