8DHB

Active FLCN GAP complex

Summary for 8DHB

• Entry DOI: 10.2210/pdb8dhb/pdb
• EMDB information: 27435
• Descriptor: Ras-related GTP-binding protein C, Folliculin, [(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate, ... (13 entities in total)
• Functional Keywords: flcn, rag-ragulator, gtpase activating protein, mtorc1 signaling, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 10
• Total formula weight: 419249.26

Authors

Jansen, R.M.,Hurley, J.H. (deposition date: 2022-06-25, release date: 2022-09-28)

• Primary citation: Jansen, R.M.,Peruzzo, R.,Fromm, S.A.,Yokom, A.L.,Zoncu, R.,Hurley, J.H.; Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation.; Sci Adv, 8:eadd2926-eadd2926, 2022; PubMed: 36103527; DOI: 10.1126/sciadv.add2926

Experimental method

ELECTRON MICROSCOPY (3.53 Å)