8DEP

Cryo-EM structure of the human reduced folate carrier, apo condition

Summary for 8DEP

Entry DOI	10.2210/pdb8dep/pdb
EMDB information	26155 26156 27394
Descriptor	Reduced folate transporter,Soluble cytochrome b562, Digitonin (2 entities in total)
Functional Keywords	reduced folate carrier, membrane protein, membrane transporter, methotrexate, slc19a1, solute carrier family 19, transport protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	1
Total formula weight	79714.44
Authors	Wright, N.J.,Fedor, J.G.,Lee, S.-Y. (deposition date: 2022-06-21, release date: 2022-09-21, Last modification date: 2022-10-12)
Primary citation	Wright, N.J.,Fedor, J.G.,Zhang, H.,Jeong, P.,Suo, Y.,Yoo, J.,Hong, J.,Im, W.,Lee, S.Y. Methotrexate recognition by the human reduced folate carrier SLC19A1. Nature, 609:1056-1062, 2022 Cited by PubMed: 36071163 DOI: 10.1038/s41586-022-05168-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.6 Å)

Structure validation