8D7R

Cryo-EM structure of human CLCF1 signaling complex: model containing the interaction core region

Summary for 8D7R

• Entry DOI: 10.2210/pdb8d7r/pdb
• Related: 8D7H
• EMDB information: 27230 27231
• Descriptor: Cardiotrophin-like cytokine factor 1, Ciliary neurotrophic factor receptor subunit alpha, Leukemia inhibitory factor receptor, ... (6 entities in total)
• Functional Keywords: cytokine signaling, clcf1, cntfr alpha, gp130, lifr, cytokine
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 226763.17

Authors

Zhou, Y.,Franklin, M.C. (deposition date: 2022-06-07, release date: 2023-03-29)

• Primary citation: Zhou, Y.,Stevis, P.E.,Cao, J.,Saotome, K.,Wu, J.,Glatman Zaretsky, A.,Haxhinasto, S.,Yancopoulos, G.D.,Murphy, A.J.,Sleeman, M.W.,Olson, W.C.,Franklin, M.C.; Structural insights into the assembly of gp130 family cytokine signaling complexes.; Sci Adv, 9:eade4395-eade4395, 2023; PubMed: 36930708; DOI: 10.1126/sciadv.ade4395

Experimental method

ELECTRON MICROSCOPY (3.9 Å)